Thursday, January 8, 2015

Panula et al., one that focused on the role of brain histamine in several disorders, including sleep, cognitive, and moto

feedamail.com TRENDS IN NEUROSCIENCES

The human histaminergic system in neuropsychiatric disorders
The neuronal histaminergic system is involved in several functions, such as the sleep–wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, and attention, all of which tend to be severely affected in neuropsychiatric disorders, such as PD, AD, HD, depression, and narcolepsy. This system has been the subject of several reviews [1–3], such as one by Haas et al., which mostly summarized animal experimental findings before 2008 [1] and two by Panula et al., one that focused on the role of brain histamine in several disorders, including sleep, cognitive, and motor disorders, and addiction, largely based upon data from animal studies [2], the other on the developmental role of brain histamine [3].
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